Science and Technology Daily Reports the Latest Research Results of HNU Professor Ju Zhenyu’s Team on the Front Page

On May 8, reporters was informed from Professor Ju Zhenyu’s Team at Hangzhou Normal University (HNU) that the team found the longevity gene Sirt6 which plays an important role in the homeostasis of hematopoietic stem cells, and it is of great significance to delay the senescence of stem cells and the prevent and treat bone marrow failure disease, which can serve as a target site for the treatment of bone marrow failure disease.

At present, there are four kinds of acetylase enzyme subtypes in the mammal. They play a role through the interaction of the same or different enzymes and enzyme substrates and participate extensively in stress regulation, fatty acid oxidation, energy metabolism and other physiological homeostasis. Because of decreasing with age, they are closely related to aging and aging related diseases. It has been found that promoting the production of protein expressed by the silencing information regulatory factor (SIRT) gene can prolong the life of lower organisms, but the specific mechanism in stem cell homeostasis is not clear.

Ju Zhenyu said that the study newly discovered the silent information regulatory factor related enzyme (Sirtuin) and the deletion of the fourth class member SIRT6 in protein family caused wingless gene (Wnt) to rise the activity of the signal pathway namely the overexpression of downstream gene, eventually leading to the depletion of hematopoietic stem cells, but using Wnt signaling pathway inhibitors can reverse the excessive proliferation and depletion of SIRT6 knockout hematopoietic stem cell.

At the same time, the study first reveals the SIRT6 can regulate the important passage of stem cells and senescence from the epigenetic level, not only providing a new potential target site and ideas for researching and intervening diseases related to aging and stem cell but also providing a new perspective for exploring the regulation of the biological function of stem cells by longevity gene Sirt6.

In recent years, Ju Zhenyu’s team has also found an important molecule (Wip1) regulating the stem cell senescence and the regeneration of tissue organ through the two signaling passages related to aging. The negative feedback regulation mechanism of DNA damage induced by this important molecular phosphatase plays an important role in stem cell senescence and tissue organ regeneration.

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Written by:HNU